With much more specific info no one is going to be able to do a lot more than guess (unless they want to cover an install from scratch... I haven't the patience). Where is the Amp getting power? Have you verified it is getting power and enough current? Does the amp have a remote/signal line? If so is it connected? If so do you hear the amps power relay kick over when the remote signal is given by the head unit? Do the head units' settings have the pre-outs turned on by default? Running wires to the Amp is nothing, if you couldn't manage that you should be changing light bulbs so I doubt that's the issue. Is the amp well grounded to a bare metal location which isn't isolated by paint?
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