It doesn't take the ECU long to adjust and learn any offsets as long as everything is already reasonably close to where it should be. The ECU can only adjust things so much, if factors are way off it's not going to get better and just start running well on its own.
Yes, just pull the EFI fuse for 30 seconds or so is all I've ever needed.
As for the bypass screw, It doesn't matter much. You'll be tuning around it with the fuel controller anyway. Just set it close to where you think it was and then worry about tuning with the NEO. The bypass airway screw is essentially just a primitive tuning device.
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